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Nomad Clinical

  • SNAP-8
SNAP-8 - Image 1

SNAP-8

€33.00

In preclinical and cellular models, researchers investigate SNAP-8 (Acetyl Octapeptide-3) to evaluate its capacity to modulate neuromuscular signaling pathways and vesicle fusion dynamics.

8 left in stock
SKU: NCSP10

As an elongated octapeptide analogue of Acetyl Hexapeptide-8 (Argireline), SNAP-8 is designed to mimic the N-terminal sequence of SNAP-25, a critical protein in the assembly of the SNARE (Soluble N-ethylmaleimide-sensitive factor Attachment Protein Receptor) complex.

By functioning as a competitive inhibitor against native SNAP-25, SNAP-8 destabilizes the SNARE complex assembly. This attenuation reduces the vesicular exocytosis of neurotransmitters, particularly acetylcholine, at the neuromuscular junction in localized cellular and dermal research models.

Key Areas of Investigation

  • SNARE Complex Assembly: Examining competitive inhibition mechanisms and ternary complex disruption against endogenous SNAP-25.

  • Neurotransmitter Release Modulation: Investigating exocytosis pathways and the inhibition of acetylcholine release at cellular junctions.

  • Dermal Matrix & Line Attenuation: Observing cellular mechanisms related to localized micro-contraction dampening and extracellular matrix preservation.

  • Structure-Activity Optimization: Evaluating the enhanced binding affinity provided by the C-terminal alanine-aspartate elongation relative to hexapeptide analogues.

  • Peptide Delivery & Transdermal Transport: Testing carrier mechanisms and topical diffusion dynamics in reconstructed skin tissue models.

Research Summary

In Simple Terms Scientific Focus
SNARE Complex Inhibition Competitive displacement of SNAP-25 during ternary SNARE assembly
Neurotransmitter Signal Dampening Attenuation of vesicular acetylcholine exocytosis at the junction
Enhanced Binding Affinity Octapeptide structure offering superior stability vs. hexapeptides
Targeted Expression Biology Reversible modulation of micro-contraction signaling pathways
Topical Matrix Integration High-compatibility octapeptide model for dermal application studies

Technical Specifications

  • Appearance: Lyophilized white to off-white cake or powder

  • Purity: High-grade analytical standard (in vitro research use)

  • Storage Requirements: Store desiccated at −20°C under an inert atmosphere for long-term molecular stability. Protect from light and moisture (methionine-containing site requires protection against oxidation). Reconstitute under sterile laboratory conditions using appropriate bacteriostatic or sterile diluents.

Research Disclaimer: IGF1-LR3 supplied by Nomad Clinical is intended exclusively for laboratory research purposes. It is not approved as a medicinal product or food supplement and is not intended for human or veterinary use. References to published scientific literature are provided for educational context only.

Attributes Value
Size

10mg

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